000 01389cam a2200169 4500
001 NMDX7450
008 120401t2017 xxu||||| |||| 00| 0 eng d
100 _aPrentice, P.
240 _aMedicine
245 _aDisorders of puberty
260 _c2017
500 _aNMUH Staff Publications
500 _a45
520 _a<span style="color: #333333; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; text-align: left; background-color: #fafafa; text-decoration-color: initial;">Puberty is the process of development of adult secondary sexual characteristics. Disorders of puberty can be classified into early (precocious) and late (delayed) puberty. Early (precocious) puberty can be secondary to either activation of the hypothalamic-pituitary-gonadal axis (gonadotrophin-dependent, or central) or altered regulation of sex hormone production in the gonads, adrenals or other tissues (gonadotrophin-independent or peripheral). Delayed puberty is most often constitutional, but hypogonadotrophic (central) and hypergonadotrophic (peripheral) hypogonadism should be considered. In this article, we discuss the clinical and biochemical features of normal and abnormal puberty.</span> 
856 _uhttp://www.medicinejournal.co.uk/article/S1357-3039(17)30158-5/abstract
856 _uhttp://ferriman.wufoo.com/forms/journal-article-request/
999 _c76345
_d76345