Principles of molecular diagnostics and personalized cancer medicine [E-Book]

Includes bibliographical references.

Section I. Introduction of Cancer Biology and Cancer Genetics: Cell proliferation and apoptosis -- Cancer stem cells -- Cell signal transduction -- Oncogenes -- Tumor suppression genes -- Viruses and human cancers: pathogenesis and therapeutic implication -- Section II. Molecular Techniques: Introduction to molecular techniques and instrumentation -- Transcriptome analysis -- Immunohistochemistry -- Cancer genomic sequencing -- Mass spectrometry: principles and applications in cancer diagnosis and management -- Cancer proteomics -- Morphoproteomics -- Flow cytometry -- Cancer cytogenomics -- DNA hypermethylation in cancer -- Single nucleotide polymorphisms -- Section III. Molecular Tests and Cancer Management: Overview of molecular tests and personalized cancer medicine -- Molecular screening, genetic counseling, and cancer prevention: Lynch Syndrome as a model -- Molecular imaging and cancer management: PET and MR agents for molecular imaging of cancer metabolism -- Detection and molecular monitoring of minimal residual diseases in myeloid neoplasms -- Molecular assessment of cancer prognosis -- Quality control, assurance, and standardization of molecular diagnostics -- Biostatistics and bioinformatics -- In vitro companion diagnostic and anti-cancer drug co-development: regulatory perspectives -- Section IV. Molecular Diagnostics of Common Malignancies: Molecular biology and pathology of lung cancer: genotype-morphology correlation -- Molecular diagnostics of breast cancer -- Colorectal cancer -- Esophageal cancer -- Prostate cancer: practical considerations for diagnosis and prognosis -- Hepatocellular carcinoma -- Pancreatic cancer -- Head and neck cancer -- Immunohistochemical and molecular diagnosis of melanoma -- Hematopoietic neoplasms -- Lymphomas -- Gynecologic neoplasms -- Bladder and kidney cancers -- Soft tissue sarcomas -- Glioma -- Pediatric neoplasms -- Metastatic malignancies -- Section V. Molecular Basis of Cancer Therapeutics: DNA repair and cancer therapeutics -- Monoclonal antibodies for the treatment of cancer -- Vaccines and cancer therapy -- Cancer gene therapy: nucleic acids as therapeutic agents -- Anti-angiogenesis therapy of cancer -- MicroRNAs and cancer therapeutics -- Molecular basis of cancer radiation treatment -- Nanotechnology and cancer therapy -- New approaches to integration of personalized medicine in early cancer drug development -- Section VI. Personalized Medicine and Targeted Therapy of Cancer: Lung cancer -- Breast cancer -- Colorectal cancer -- Esophageal cancer -- Gastric cancer -- Prostate cancer -- Hepatocellular carcinoma -- Pancreatic cancer: current status and proposed strategies -- Neuroendocrine neoplasms -- Head and neck cancer -- Melanoma -- Leukemia -- Gynecologic cancers -- Renal cell carcinoma -- Gliomas -- Osteosarcoma -- Molecular basis of chemoradiotherapy and high-precision radiotherapy -- Section VII. Future of Molecular Diagnostics and Personalized Cancer Medicine: New approaches to personalized medicine and targeted drug discovery -- The future of molecular diagnostics in oncology.

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today's subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention.all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

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