TY  - BOOK
AU  - Taylor,Kathleen
TI  - The Fragile Brain: the strange, hopeful science of dementia
SN  - 0191039020
PY  - 2016///
CY  - Oxford
PB  - OUP Oxford
KW  - Dementia
KW  - Alzheimer's disease
KW  - Brain
KW  - Physiology
KW  - Nervous system
KW  - Degeneration
N1  - Includes bibliographical references (pages [229]-310) and index; Cover; the Fragile Brain: The Strange, Hopeful Science of Dementia; Copyright; CONTENTS; List of Figures; LIST OF TABLES; ACKNOWLEDGEMENTS ; ORGANIZATIONS; UK; US; Europe; Australia; Other countries; Chapter 1: Fragile Brains ; Part 1: The Problem; Chapter 2: Living Well and Growing Old; The Links to Lifestyle ; Barriers to Change ; Chapter 3: Counting the Costs; Dementia Expenses; Dementia Spending; Global Costs; Is Prevention Better than Cure?; Chapter 4: Brain Disorders Affect All of Us ; The Hope; A Roadmap; Chapter 5: Discovering Dementia; The Dying Brain; Symptoms; Brain Changes; VentriclesNeurotransmitters and Ion Channels; The Marvel of Fat ; Glutamate and the Power of Calcium ; GABA ; Deep Brain Transmitters ; Synapses; Myelin; Wiring Damage ; From Birth to Death in the Brain; Dementia: A Problem of Association?; Brain and Mind; Chapter 6: Protein Problems; The Amyloid Cascade ; A Brief Guide to Protein Production; Location, Location, Location ; The Vital Start; APP's Butchers; Which Amyloid?; Protein not Wanted; Chapter 7: Too Much Amyloid?; A Dip into Physics; 'Protein Function is Governed by Shape and Charge'; Gene Control; Amyloid Production; Chapter 8: Transfers In?Travelling Blood; Where Blood Meets Brain; Endothelial Cells; Amyloid Entry; 9: How to Clean Your Brain; Blood; Cerebrospinal Fluid; Windows on the Brain; Interstitial Fluid; Lymph; Flushing out Amyloid; Deportation; Destruction; Internal Waste Disposal; Outside the Cell; Part 2: Risk Factors; 10: Interpreting Risk Factors; Too Much to Study; From Quality to Quantity; Dissecting the Numbers; 11: The Inescapables-Age, Gender, and Genes; Getting Old; Hope You Die Before You Get Old?; DNA Damage and Repair; Growth and Ageing; Failing Power Supplies; Oxidative Stress; Being FemaleHaving Certain Gene Variants; ApoE and cholesterol; ApoE and disease; 12: Injury and Surgery; Traumatic Brain Injury; Surgery and General Anaesthesia; Chapter 13: Infection and Inflammation; Three Functions of the Immune System; The Enemies; The Detectives; Signs of Danger; Cells and Chemicals; The Naming of Names; Go Forth and Multiply; The Counter-attack; Innate Immune Cells; Adaptive Immune Cells; Fluid Defences; Cytokines; The Signs of Inflammation ; Reaching the Brain ; Context is Everything ; Microglia; Neuroinflammation ; Weakened Before You Were Born?; Chapter 14: Big KillersThe Heart and the Blood; The Vulnerable Border; Diabetes; The Glucose Trap; The Dangers of High Blood Sugar; Your Energetic Brain; Insulin and the Brain; Needier Cells Die Younger?; Cancer; Stem Cells; Troubled Bodies, Troubled Minds; Depression; Schizophrenia; Stress; Chapter 15: Consumerism, Literally; Diet and Obesity; Food Quality and Food Habits; Passing on the Problems; Foods versus Diets; Low Levels of Micronutrients; Red Meat and Dairy ; Processed Foods; Quick Fix or Slow Change?; Caveat Lector-Reader Beware; Chapter 16: Exercise; Moving is Good for You
N2  - In Fragile Brains Kathleen Taylor looks at the genetic and lifestyle factors currently linked to the development of dementia, focusing on important new research on how the immune system operates in the brain
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