TY - BOOK AU - Wiersinga, W J (ed) AU - Seymour, C W (ed) TI - Handbook of sepsis SN - 9783319735054 PY - 2018/// CY - Cham PB - Springer International Publishing N1 - Text covers: What is sepsis; The epidemiology of Sepsis; Pathogenesis of Sepsis; The coagulation system in Sepsis; The endocrine system in sepsis; Sepsis biomarkers; International clinical practice guidelines; Fluids in Sepsis; Vasopressors in Sepsis; Management of multiorgan failure in Sepsis; Sepsis management: importance of the pathogen; Antimicrobial therapy; Adjunctive immunotherapy; Novel trial design in Sepsis; Sepsis in low-and middle-income countries; Sepsis: the road ahead N2 - This book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented ER -