Textbook of clinical embryology [E-Book]

Includes bibliographical references and index.

"The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook - inspired by the postgraduate degree program at the University of Oxford - guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology"--Provided by publisher

Print version record.

Cover; Contents; Contributors; Foreword; Preface; Section 1 Mammalian reproductive physiology; Chapter 1 Sexual reproduction: an overview; Introduction; Gamete generation and selection; Social and behavioural gamete selection; Fertilization; Embryo development and gestation; Reproductive strategies; Population dynamics; Summary; References; Chapter 2 Sexual development; Introduction; Development of the reproductive organs: an overview; The cell biology of the developing gonads; Supporting cell lineage; Germ cells; Steroidogenic cells; Endothelial cells; Peritubular myoid cells.

The genetic control of sexual developmentIdentification of SRY and its role in testis determination; SOX9: a key vertebrate testis-determining gene; Spreading the masculinizing signal: FGF9; Building the ovary; Maintaining the ovary: FOXL2; The opposing forces of male and female sex-determining genes; Summary and concluding remarks; Acknowledgements; Bibliography; Chapter 3 The male reproductive tract and spermatogenesis; Objectives; Structure and function of the male reproductive system; Testes; Epididymis; Vas deferens; Urethra; Seminal vesicles; Prostate gland; Bulbourethral glands; Penis.

Male reproductive tract development and differentiationSpermatogenesis; ; Mitosis phase; Meiosis phase; Spermiogenesis phase; Hormonal regulation; ; Summary; References; Chapter 4 Female reproductive tract and oocyte development; Introduction; Ovary; Oviduct; Uterus; Cervix; Vagina; Oocyte development; ; Follicle size; Primordial follicle growth resumption; Zona pellucida; Follicle development; Intrafollicular signalling; Gap junctions; Oocyte signalling; Oocyte health; Acknowledgements; References; Chapter 5 Ovulation and regulation of the menstrual cycle; Introduction.

Hypothalamic and pituitary contributionA brief overview of folliculogenesis; Stages of the menstrual cycle; The follicular phase; Selection of the dominant follicle; The LH surge; Ovulation; The luteal phase; Structural changes within the endometrium during menstruation and subsequent phases of the cycle; Summary; References; Chapter 6 Key events in early oogenesis affecting oocyte competence in women; Introduction; Timeline of oogenesis; Female meiosis; Abnormalities arising during meiosis; Oocyte growth; Conclusions; Acknowledgements; References; Chapter 7 Regulation of gonadal function.

IntroductionThe GnRH pulse generator; The anterior pituitary gland; The menstrual cycle; Modulation of the GnRH pulse generator and feedback mechanisms; Control of GnRH pulses; HPO feedback loops; Inhibins/activins/follistatin; Endogenous opiates; Clinical implications: GnRH agonists and antagonists; References; Chapter 8 Reproductive endocrinology; Steroid hormones; Steroid biosynthesis; Steroids of the adrenal cortex; Regulation of adrenal steroid synthesis; Disorders resulting from defects in steroid biosynthesis; Gonadal steroid hormones; Steroid-binding proteins; Menarche.

WorldCat record variable field(s) change: 650