Haschek and Rousseaux's handbook of toxicologic pathology

Biochemical and Molecular Basis of Toxicity -- Pharmacokinetics and Toxicokinetics -- Principles of Pharmacodynamics and Toxicodynamics -- Morphologic Manifestations of Toxic Cell Injury -- Carcinogenesis: Mechanisms and Manifestations -- Basic Approaches in Anatomic Toxicologic Pathology -- Special Techniques in Toxicologic Pathology -- Stereological Principles and Sampling Procedures for Toxicologic Pathologists -- In Vivo Small Animal Imaging: A Comparison with Gross and Histopathologic Observations in Animal Models -- Biomarkers: Discovery, Qualification and Application -- The Application of Toxicogenomics to the Interpretation of Toxicologic Pathology -- Genetically Engineered Animals in Product Discovery and Development -- The Use of Minipigs in Non-Clinical Research -- Alternative Animal Models -- Pathology and GLPs, Quality Control and Quality Assurance -- Nomenclature -- Peer Review and Pathology Working Groups -- Clinical Pathology in Non-Clinical Toxicology Testing -- Pathology Issues in the Design of Toxicology Studies -- Issues in Laboratory Animal Science -- Overview of Drug Development -- Overview of the Role of Pathology in Product Discovery and Safety Assessment -- Discovery Toxicology and Pathology -- Pathology in Non-Clinical Drug Safety Assessment -- Biopharmaceuticals -- Biomedical Materials and Devices -- Carcinogenicity Assessment -- Preparation of the Pathology Report for a Toxicology Study -- Interpretation of Clinical Pathology Results in Non-Clinical Toxicology Testing -- Statistical Assessment of Toxicologic Pathology Studies -- Risk Assessment -- Risk Communication for Toxicologic Pathologists -- Risk Management in Non-Clinical Drug Development -- Environmental Toxicologic Pathology and Human Health -- Food and Toxicologic Pathology: An Overview -- Nutritional Toxicologic Pathology -- Endocrine Disruptors -- Phycotoxins -- Mycotoxins -- Selected Poisonous Plants Affecting Animal and Human Health -- Heavy Metals -- Agricultural Chemicals -- Nanoparticulates -- Radiation and Other Physical Agents -- Liver and Gall Bladder -- Cardiac, Vascular, and Skeletal Muscle Systems -- Kidney -- Lower Urinary Tract -- Immune System -- Hematopoietic System -- Respiratory System -- Nervous System -- Eye -- Ear -- Integument -- Digestive Tract -- Exocrine Pancreas -- Endocrine System -- Male Reproductive System -- Female Reproductive System -- Mammary Gland -- Embryo and Fetus -- Bone and Joints.

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings. Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology. Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations.