MARC details
| 000 -LEADER |
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| fixed length control field |
07029cam a2200769 a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
ocn810933230 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20230822091129.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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| fixed length control field |
m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr cnu---unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
120924s2012 si a ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
N$T |
| 066 ## - CHARACTER SETS PRESENT |
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| Alternate G0 or G1 character set |
(S |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
101591269 |
| Source |
DNLM |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
016436891 |
| Source |
Uk |
| 019 ## - |
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| -- |
810317523 |
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811504359 |
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817811957 |
| -- |
1058195598 |
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1065858806 |
| -- |
1081227950 |
| -- |
1086441892 |
| -- |
1228617944 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9789814335362 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9814335363 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
128359367X |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9781283593670 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
9789814335355 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
9814335355 |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
478625 |
| -- |
(N$T) |
| 035 ## - SYSTEM CONTROL NUMBER |
|---|
| System control number |
(OCoLC)810933230 |
| Canceled/invalid control number |
(OCoLC)810317523 |
| -- |
(OCoLC)811504359 |
| -- |
(OCoLC)817811957 |
| -- |
(OCoLC)1058195598 |
| -- |
(OCoLC)1065858806 |
| -- |
(OCoLC)1081227950 |
| -- |
(OCoLC)1086441892 |
| -- |
(OCoLC)1228617944 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
2012 G-642 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
QW 568 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI |
| Subject category code subdivision |
007000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJCM |
| Source |
bicssc |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
MAIN |
| 245 04 - TITLE STATEMENT |
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| Title |
The MIF handbook |
| Statement of responsibility, etc |
|
| Medium |
[E-Book] |
| 260 ## - PUBLICATION INFORMATION |
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| Place of publication |
Singapore ; |
| -- |
Hackensack, NJ. : |
| Publisher |
World Scientific, |
| Date |
2012. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Physical description |
1 online resource (viii, 390 pages) : |
| Other physical details |
illustrations |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 520 ## - ABSTRACT |
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| Abstract |
The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science. |
| 505 0# - CONTENTS |
|---|
| Contents |
Preface; Part I MIF Structure and Mechanism of Action; I-1 MIF, MIF Alleles, and the Regulation of the Host Response Richard Bucala; 1. Introduction; 2. MIF Gene; 3. MIF Production and Signal Transduction; 4. Innate Immunity; 5. Adaptive Immunity; 6. MIF Integrates Immune, Metabolic, and Oncogenic Responses; 7. MIF Alleles in Human Disease; 8. Therapeutic Implications and Future Directions; Acknowledgments; References; I-2 MIF and the Chemokine Axis Sandra Kraemer, Christian Weber and J�urgen Bernhagen; 1. Introduction; 2. Chemokines: Classes, Structure, Function, and Receptors. |
| 505 8# - CONTENTS |
|---|
| Contents |
3. Structural Classification of MIF4. Nonclassical MIF Secretion and Link to Secretion of CLF Chemokines; 5. Chemokine-like Function (CLF) Chemokines and MIF as a CLF Chemokine; 6. MIF/ Chemokine Receptor Interactions and Functional Role in Inflammation and Atherogenesis; 7. Structural Basis Underlying MIF/Chemokine Receptor Interactions; 8. MIF Receptor Complexes; 9. Conclusion; 10. Acknowledgments; References; I-3 CD74, the Natural Receptor for MIF, Regulates Cell Survival in Health and Disease Idit Shachar, Maya Gordin, Sivan Cohen, Inbal Binsky, Ayelet Marom and Shirly Becker-Herman. |
| 505 8# - CONTENTS |
|---|
| Contents |
1. Introduction2. CD74 (Invariant Chain, Ii); 3. CD74 Functions as a Chaperone for MHC Class II; 4. CD74 as a Signaling Molecule; 4.1 CD74 is a cell surface receptor that induces signaling cascades; 4.2 CD74 is subjected to regulated intramembrane proteolysis (RIP); 5. MIF Regulates B Cell Survival in a CD74-Dependent Manner; 5.1 A complex of CD74 and CD44 is essential for initiating the signaling cascade induced by MIF; 5.2 c-Met and its ligand HGF regulate mature B cell survival in a pathway induced by MIF binding to CD74/CD44. |
| 505 8# - CONTENTS |
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| Contents |
5.3 MIF induces TAp63 expression, which regulates B cell survival in a CD74-dependent manner6. MIF Is Secreted from Perivascular Bone Marrow Dendritic Cell Clusters that Regulate B Cell Survival; 7. MIF and CD74 in Tumors; 7.1 MIF and CD74 in CLL survival; 7.2 MIF and CD74 regulate CLL homing to the BM; References; I-4 Towards the MIF Interactome J�org Klug and Andreas Meinhardt; 1. Introduction; 2. MIF Affects Degradation of Regulatory Proteins by Modulating the Ubiquitin Proteasome System; 3. Ribosomal Protein S19 as Endogenous Inhibitor of Extracellular MIF. |
| 590 ## - LOCAL NOTE (RLIN) |
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| Local note |
WorldCat record variable field(s) change: 650 |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Cytokines. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Immune response |
| General subdivision |
Regulation. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Macrophages |
| General subdivision |
Activation. |
| 650 22 - SUBJECT HEADINGS |
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| Subject term |
Macrophages |
| General subdivision |
metabolism |
| 650 12 - SUBJECT HEADINGS |
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| Subject term |
Macrophage Migration-Inhibitory Factors |
| General subdivision |
physiology |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Macrophage Activation |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Macrophage Migration-Inhibitory Factors |
| General subdivision |
genetics |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Macrophage Migration-Inhibitory Factors |
| General subdivision |
immunology |
| 650 #2 - SUBJECT HEADINGS |
|---|
| Subject term |
Cytokines |
| 650 #4 - SUBJECT HEADINGS |
|---|
| Subject term |
Immune response |
| General subdivision |
Regulation. |
| 650 #4 - SUBJECT HEADINGS |
|---|
| Subject term |
Cytokines. |
| 650 #4 - SUBJECT HEADINGS |
|---|
| Subject term |
Medicine. |
| 700 1# - ADDED PERSONAL NAME |
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| Added personal author |
Bucala, Richard. |
| 856 40 - ONLINE RESOURCE |
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| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=478625">https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=478625</a> |
| Link text |
Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Suppress in OPAC |
Do not Suppress in OPAC |
| 588 0# - SOURCE OF DESCRIPTION NOTE |
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| Source of description note |
Print version record. |
| 880 8# - ALTERNATE GRAPHIC REPRESENTATION |
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| Linkage |
505-00/(S |
| a |
4. Interactors Involved in MIF Redox Activity4.1. Insulin; 4.2. Hepatopoietin (HPO); 4.3. Proliferation-associated gene (PAG) protein; 4.4. p53; 4.5. Protein (NM23A) expressed in nonmetastatic cells (NM23-H1); 4.6. (Sa(B1-inhibitor-3 ((Sa(B1-I3); 5 Concluding Remarks; Acknowledgments; References; I-5 Structural Studies of Small Molecule Inhibitors of MIF Yoonsang Cho and Elias J. Lolis; 1. Introduction; 2. Small Molecule Structures; 3. Catalytic Site Inhibitors; 4. Covalent Inhibitors; 5. Allosteric and Mixed Inhibitors; References; Part II Regulation of MIF Expression. |
| 938 ## - |
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Askews and Holts Library Services |
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ASKH |
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AH24256233 |
| 938 ## - |
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Coutts Information Services |
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COUT |
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24020448 |
| 938 ## - |
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ProQuest Ebook Central |
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EBLB |
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EBL1019615 |
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EBSCOhost |
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EBSC |
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478625 |
| 938 ## - |
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ProQuest MyiLibrary Digital eBook Collection |
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IDEB |
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390612 |
| 938 ## - |
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YBP Library Services |
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YANK |
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7583608 |
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92 |
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N$T |