Atkinson's principles of clinical pharmacology (Record no. 88158)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03103pam a22002291i 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201112s2021 ne a ob 001|0|eng|d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| ISBN | 9780128198698 |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | QV 21 |
| 130 0# - MAIN ENTRY--UNIFORM TITLE | |
| Uniform title | Principles of clinical pharmacology. |
| 245 10 - TITLE STATEMENT | |
| Title | Atkinson's principles of clinical pharmacology |
| 250 ## - EDITION | |
| Edition statement | 4th ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | London : |
| Name of producer, publisher, distributor, manufacturer | Academic Press, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Physical description | xxi, 739p |
| 336 ## - CONTENT TYPE | |
| Content type term | still image |
| Source | rdacontent |
| 500 ## - GENERAL NOTE | |
| General note | Previous edition: 2012. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 505 0# - CONTENTS | |
| Contents | <p>1. Introduction</p> <p><b>PART 1: PHARMACOKINETICS </b>2. Clinical pharmacokinetics 3. Compartmental analysis of drug distribution 4. Drug absorption and bioavailability 5. Effects of renal disease on pharmacokinetics 6. Kinetics of hemodialysis and hemofiltration 7. Effects of liver disease on pharmacokinetics 8. Noncompartmental vs. compartmental approaches to pharmacokinetic analysis 9. Distributed models of drug kinetics 10. Population pharmacokinetics</p> <p><b>PART 2: DRUG METABOLISM AND TRANSPORT </b>11. Pathways of drug metabolism 12. Biochemical mechanisms of drug toxicity 13. Chemical assay of drugs and drug metabolites 14. Equilibrative and concentrative transport 15. Pharmacogenetics 16. Drug interactions</p> <p><b>PART 3: ASSESSMENT OF DRUG EFFECTS </b>17. Physiological and laboratory markers of drug effect 18. Dose response and concentration response analysis 19. Kinetics of pharmacologic effect 20. Disease progression models </p> <p><b>PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY </b>21. Sex differences in pharmacokinetics and pharmacodynamics 22. Drug therapy in pregnant and nursing women 23. Drug therapy in neonates and pediatric patients 24. Drug therapy in the elderly 25. Clinical analysis of adverse drug reactions 26. Quality assessment of drug therapy</p> <p><b>PART 5: DRUG DISCOVERY AND DEVELOPMENT </b>27. Project management 28. Drug discovery 29. Pre-clinical development 30. Animal scale up 31. Phase I studies 32. PK and PD considerations in the development of biotechnology products and large molecules 33. Design of clinical development programs 34. Good design practices for clinical trials 35. Role of the FDA in guiding drug development</p> <p>Appendix I. Table of Laplace Transforms II. Answers to Study Problems</p> |
| 520 ## - ABSTRACT | |
| Abstract | Atkinson's Principles of Clinical Pharmacology, fourth edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. |
| 650 #0 - SUBJECT HEADINGS | |
| Subject term | Clinical pharmacology |
| 700 1# - ADDED PERSONAL NAME | |
| Added personal author | Huang, Shiew-Mei |
| Relator term | editor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Suppress in OPAC | Do not Suppress in OPAC |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type | Total Checkouts |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | Whipps Cross Library (Barts Health) | Whipps Cross Library (Barts Health) | Shelves | 11/10/2022 | QV 21 HUA | BARTS005286 | 11/10/2022 | 11/10/2022 | Book | |||||
| National Library of Medicine | Whittington Health Library | Whittington Health Library | Shelves | 21/07/2023 | QV 21 HUA | 00024791 | 21/07/2023 | 21/07/2023 | Book |